Next to a mouthwatering beef roast, brisket is one of my favorite dishes to cook. I submerged the brisket in bbq sauce, with chopped onions and green and red peppers, set the oven to 250. The key to a mouthwatering brisket that falls off your fork, low and slow. The longer you cook the brisket at a lower temp the more tender and moist the meat is.